Recreational genetics

Mt-Genograf® — the maternal line test

Mitochondrial DNA is inherited exclusively from the mother by all her children, and travels through the generations almost unchanged for thousands to tens of thousands of years. Mt-Genograf® reads your maternal profile and clan from it, and so reveals the prehistory of your maternal line.

Maternal lineThe test can be carried out on male and female samples alike

Your maternal clan reflects the prehistory of your line over thousands to tens of thousands of years.

What is mitochondrial DNA?

Besides the cell nucleus, which holds the “classic” DNA, DNA is also found in another part of the cell (an organelle) — the mitochondrion. A mitochondrion can be likened to a “power station” inside the cell, because it produces the energy needed for every biochemical reaction. Mitochondrial DNA (which we abbreviate to mtDNA) is completely different from nuclear DNA and follows somewhat different rules. Above all, mtDNA is arranged in a circle rather than in chromosomes, which makes it more like bacterial DNA. Overall it makes up only a tiny fraction of a person's genetic information, since it contains just 37 genes, and the mitochondrion uses all of their products (proteins) for its own functioning.

The most interesting thing about mtDNA, however, is that it is inherited only from the mother. This is known as maternal inheritance: a mother passes her mtDNA on to all her children, both daughters and sons, whereas a father cannot pass his on at all. This fact is used above all in studying family trees and family ties along the maternal line, and also, for example, in studying the migration of ancestors.

Mitochondrial DNA, or mtDNA, is inherited only from the mother — this is known as maternal inheritance. A mother passes her mtDNA on to all her children, daughters and sons alike, whereas a father cannot pass his on.

What we do with your sample

We need your sample in order to look at what your mitochondrial DNA looks like in the region known as HVR1. That gives us your maternal genetic profile (your Mt-profile), which determines which maternal clan you belong to.

The test can be carried out on male and female samples alike.

Why is it worth knowing your maternal profile and clan?

Your maternal clan determines the prehistory of the maternal line being tested over thousands to tens of thousands of years. Genetic mapping of the world's population has shown that certain maternal clans occur more frequently in certain geographical areas and less frequently in others, and that they have different histories and different ages. By comparing a maternal profile with profiles obtained in various geographical locations or among different ethnic groups, we can determine which maternal clan it belongs to, and with it the most likely origin of the line being tested.

A maternal profile can also be compared with the maternal profiles of other people, and so confirm or rule out a presumed kinship between two maternal lines during genealogical research. Where maternal profiles match fully in the HVR1 region, current knowledge puts the most likely maternal ancestor around 100 generations back.

With every version of the test we offer free access to the Czech National Genographic Database, through which you can contact users with matching variations and perhaps find your relatives. More about the database and access to it.

What is the difference between the basic and extended versions?

Mt-Genograf® comes in 3 versions — basic without a certificate, basic with a certificate, and the extended GENEA®.

Would you like to upgrade your basic test to GENEA®?

Have you already taken the basic Mt-Genograf® test and would like to upgrade it to the more precise GENEA® test? Call or write to us — we will be glad to advise you.